Design, synthesis and biological evaluation of substituted 11H-benzo[a]carbazole-5-carboxamides as novel antitumor agents

2,2,2-Trichloro-<i>N</i>-({2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1<i>H</i>-benzo[de]isoquinolin- 5-yl}carbamoyl)acetamide (UNBS3157), a Novel Nonhematotoxic Naphthalimide Derivative with Potent Antitumor Activity

Eric Van Quaquebeke, Tine Mahieu, Patrick Dumont et al. · Journal of Medicinal Chemistry · 2007 · 126 citations

Medicine, Medicinal Chemistry, Pharmacology +12

New Analogues of Amonafide and Elinafide, Containing Aromatic Heterocycles:  Synthesis, Antitumor Activity, Molecular Modeling, and DNA Binding Properties

Miguel F. Braña, Mónica Cacho, Mario A. García et al. · Journal of Medicinal Chemistry · 2004 · 111 citations

Pharmacy, Chemistry, Medicinal Chemistry +11

Paradoxical relationship between acetylator phenotype and amonafide toxicity

Mark J. Ratain, Rosemarie Mick, F Berezin et al. · Clinical Pharmacology & Therapeutics · 1991 · 82 citations

Pharmacy, Pharmacokinetics, Pharmacology +15

R16, a novel amonafide analogue, induces apoptosis and G2-M arrest via poisoning topoisomerase II

Hong Zhu, Min Huang, Fan Yang et al. · Molecular Cancer Therapeutics · 2007 · 79 citations · Full text

Medicine, Oncology, Pharmacology +13

Synthesis, biological evaluation and DNA binding properties of novel mono and bisnaphthalimides

Miguel F. Braña, Mónica Cacho, Ana Ramos et al. · Organic & Biomolecular Chemistry · 2003 · 69 citations

Pharmacy, Medicinal Chemistry, Oncology +10