Sustained morphine treatment augments basal CGRP release from cultured primary sensory neurons in a Raf-1 dependent manner

A general role for adaptations in G-proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function

Rose Z. Terwilliger, Dana Beitner‐Johnson, Kevin A. Sevarino et al. · Brain Research · 1991 · 540 citations · Full text

Life Sciences, Neuroscience, Pharmacology +17

Sustained Morphine Exposure Induces a Spinal Dynorphin-Dependent Enhancement of Excitatory Transmitter Release from Primary Afferent Fibers

Luis R. Gardell, Ruizhong Wang, Shannon E. Burgess et al. · Journal of Neuroscience · 2002 · 253 citations · Full text

Life Sciences, Neuroscience, Pharmacology +17

PKA/AKAP/VR-1 Module: A Common Link of G_s-Mediated Signaling to Thermal Hyperalgesia

P. K. Rathee, Carsten Distler, Otilia Obreja et al. · Journal of Neuroscience · 2002 · 243 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Modulation of opioid analgesia, tolerance and dependence by Gs-coupled, GM1 ganglioside-regulated opioid receptor functions

Stanley M. Crain, Ke-Fei Shen · Trends in Pharmacological Sciences · 1998 · 150 citations

Medicine, Neuroscience, Pharmacology +14

Blockade and reversal of spinal morphine tolerance by peptide and non‐peptide calcitonin gene‐related peptide receptor antagonists

Kelly J. Powell, Weiya Ma, Maaja Sutak et al. · British Journal of Pharmacology · 2000 · 125 citations · Full text

Medicine, Anesthesiology, Pharmacology +17