Stanley M. Crain

A general role for adaptations in G-proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function

Rose Z. Terwilliger, Dana Beitner‐Johnson, Kevin A. Sevarino et al. · Brain Research · 1991 · 540 citations · Full text

Dual opioid modulation of the action potential duration of mouse dorsal root ganglion neurons in culture

Kai Shen, Stanley M. Crain · Brain Research · 1989 · 214 citations

Health Sciences, Neurophysiology, Pain Medicine +14

Ultra-low concentrations of naloxone selectively antagonize excitatory effects of morphine on sensory neurons, thereby increasing its antinociceptive potency and attenuating tolerance/dependence during chronic cotreatment.

Stanley M. Crain, Kai Shen · Proceedings of the National Academy of Sciences · 1995 · 204 citations · Full text

Inhibitory Apd-shortening Effects, Pain Medicine, Molecular Pain +21

Acute thermal hyperalgesia elicited by low-dose morphine in normal mice is blocked by ultra-low-dose naltrexone, unmasking potent opioid analgesia

Stanley M. Crain, Ke-Fei Shen · Brain Research · 2001 · 152 citations

Acute Pain, Pain Medicine, Low-dose Morphine +9

Modulation of opioid analgesia, tolerance and dependence by Gs-coupled, GM1 ganglioside-regulated opioid receptor functions

Stanley M. Crain, Ke-Fei Shen · Trends in Pharmacological Sciences · 1998 · 150 citations

Molecular Pharmacology, Health Sciences, Functional Selectivity +13