Modulation of opioid analgesia, tolerance and dependence by Gs-coupled, GM1 ganglioside-regulated opioid receptor functions

Tolerance of locus coeruleus neurones to morphine and suppression of withdrawal response by clonidine

George K. Aghajanian · Nature · 1978 · 800 citations

Medicine, Neuroscience, Pharmacology +14

A general role for adaptations in G-proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function

Rose Z. Terwilliger, Dana Beitner‐Johnson, Kevin A. Sevarino et al. · Brain Research · 1991 · 540 citations · Full text

Life Sciences, Neuroscience, Pharmacology +17

Desensitization of G-protein-coupled Receptors

Zhan Xiao, Yihong Yao, Long Yu et al. · Journal of Biological Chemistry · 1999 · 526 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Phosphorylation and Desensitization of the Human β1-Adrenergic Receptor

Neil J. Freedman, Stephen B. Liggett, Douglas E. Drachman et al. · Journal of Biological Chemistry · 1995 · 323 citations · Full text

Life Sciences, Pharmacology, Cell Signaling +16

An opiate-receptor gene family reunion

George R. Uhl, Steven R. Childers, Gavril W. Pasternak · Trends in Neurosciences · 1994 · 285 citations

Life Sciences, Genetics, Molecular Genetics +3