The cAMP signaling system inhibits the repair of γ-ray-induced DNA damage by promoting Epac1-mediated proteasomal degradation of XRCC1 protein in human lung cancer cells

Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange.

Larry H. Thompson, Kerry W. Brookman, Nigel J. Jones et al. · Molecular and Cellular Biology · 1990 · 401 citations

Life Sciences, Genetics, Molecular Biology +17

The Protein Kinase CK2 Facilitates Repair of Chromosomal DNA Single-Strand Breaks

Joanna I. Loizou, Sherif F. El‐Khamisy, Anastasia Zlatanou et al. · Cell · 2004 · 329 citations · Full text

Life Sciences, Genetics, Molecular Biology +11

Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage

Ho Chul Kang, Yun-Il Lee, Joo‐Ho Shin et al. · Proceedings of the National Academy of Sciences · 2011 · 262 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +13

Activation of the alpha subunit of Gs in intact cells alters its abundance, rate of degradation, and membrane avidity.

Mark J. Levis, Henry R. Bourne · The Journal of Cell Biology · 1992 · 209 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

DNA Damage Responses: Mechanisms and Roles in Human Disease

Michael B. Kastan · Molecular Cancer Research · 2008 · 185 citations · Full text

Life Sciences, Genetics, Molecular Biology +17