Dysregulation of the expression and secretion of inflammation-related adipokines by hypoxia in human adipocytes

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

G L Wang, Bing‐Hua Jiang, E A Rue et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations

Life Sciences, Cell Biology, Molecular Biology +17

Hypoadiponectinemia in Obesity and Type 2 Diabetes: Close Association with Insulin Resistance and Hyperinsulinemia

Christian Weyer, Tohru Funahashi, Sachiyo Tanaka et al. · The Journal of Clinical Endocrinology & Metabolism · 2001 · 3.4K citations · Full text

Medicine, Biochemistry, Endocrinology +12

AdipoQ Is a Novel Adipose-specific Gene Dysregulated in Obesity

Erding Hu, Peng Liang, Bruce M. Spiegelman · Journal of Biological Chemistry · 1996 · 2.3K citations · Full text

Life Sciences, Genetics, Molecular Genetics +12

Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1

Gregg L. Semenza, Bing‐Hua Jiang, Sandra W. Leung et al. · Journal of Biological Chemistry · 1996 · 1.8K citations · Full text

Medicine, Molecular Biology, Molecular Genetics +15

Adiponectin, an Adipocyte-Derived Plasma Protein, Inhibits Endothelial NF-κB Signaling Through a cAMP-Dependent Pathway

Noriyuki Ouchi, Shinji Kihara, Yukio Arita et al. · Circulation · 2000 · 1.7K citations

Life Sciences, Cell Biology, Molecular Biology +17