Dietary Flavonoids Modulate CYP2C to Improve Drug Oral Bioavailability and Their Qualitative/Quantitative Structure–Activity Relationship

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

Tsutomu Shimada, Hiroshi Yamazaki, Mayumi Mimura et al. · Journal of Pharmacology and Experimental Therapeutics · 1994 · 2.8K citations

Medicine, Biochemistry, Pharmacology +15

Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes

Victoria A. Eagling, John Tjia, David Back · British Journal of Clinical Pharmacology · 1998 · 336 citations · Full text

Medicine, Pharmacology, Biochemical Pharmacology +14

A Constituent of Green Tea, Epigallocatechin-3-gallate, Activates Endothelial Nitric Oxide Synthase by a Phosphatidylinositol-3-OH-kinase-, cAMP-dependent Protein Kinase-, and Akt-dependent Pathway and Leads to Endothelial-dependent Vasorelaxation

Mario Lorenz, Elena Follmann, Wanda Michaelis et al. · Journal of Biological Chemistry · 2004 · 332 citations · Full text

Veterinary Medicine, Biochemistry, Pharmacology +15

Evaluation of Cytochrome P450 Probe Substrates Commonly Used by the Pharmaceutical Industry to Study in Vitro Drug Interactions

Rae Yuan, Soraya Madani, Xiaoxiong Wei et al. · Drug Metabolism and Disposition · 2002 · 324 citations

Medicine, Pharmacokinetics, Pharmacology +16

Citrus Polyphenol Hesperidin Stimulates Production of Nitric Oxide in Endothelial Cells while Improving Endothelial Function and Reducing Inflammatory Markers in Patients with Metabolic Syndrome

Stefano Rizza, Ranganath Muniyappa, Micaela Iantorno et al. · The Journal of Clinical Endocrinology & Metabolism · 2011 · 320 citations · Full text

Veterinary Medicine, Biochemistry, Pharmacology +14