Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

Donald W. Nicholson, Ambereen Ali, Nancy A. Thornberry et al. · Nature · 1995 · 4K citations

Protein Function, Biochemistry, Ice/ced-3 Protease +11

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

Marta Muzio, Arul M. Chinnaiyan, Frank Kischkel et al. · Cell · 1996 · 3K citations · Full text

Death-inducing Signaling Complex, Signal Transduction, Signaling Pathway +11

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

Naoto Itoh, Shin Yonehara, Ai Ishii et al. · Cell · 1991 · 2.8K citations

Molecular Immunology, Apoptosis, Immunology +9

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

Yuri Lazebnik, Scott H. Kaufmann, Serge Desnoyers et al. · Nature · 1994 · 2.6K citations

Protein Chemistry, Biochemistry, Viral Polymerase Structure +6

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

Cell · 1993 · 2.5K citations · Full text

Cytokine, Signaling Pathway, Cell Regulation +11