Introduction of chiral 2-(aminoalkyl) substituents into 5-amino-1,3-oxazol-4-ylphosphonic acid derivatives and their use in phosphonodipeptide synthesis

Abstract

Starting from phthalimidoalkanoylamines <bold>1</bold> we have suggested a synthetic route to 5-amino-1,3-oxazol-4-ylphosphonic acid derivatives <bold>5</bold> , which have been further used to obtain phosphonodipeptides <bold>8</bold>, <bold>9</bold>, and <bold>10</bold> with the original optical purity retained.