Concepedia

A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity

Radina Kostadinova, Franziska Boess, Dawn Applegate, Laura Suter‐Dick, Thomas Weiser, Thomas P. Singer, Brian A. Naughton, Adrian Roth

Toxicology and Applied Pharmacology · 2013 · 258 citations · 67 references

DOI

Concepts

References

67

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

J�rgen Lehmann, David D. McKee, M. A. Watson et al. · Journal of Clinical Investigation · 1998 · 1.6K citations · Full text

, , +14

Microscale culture of human liver cells for drug development

Salman R. Khetani, Sangeeta N. Bhatia · Nature Biotechnology · 2007 · 1.2K citations

, , +14

Genome-wide expression monitoring in Saccharomyces cerevisiae

Lisa Wodicka, Helin Dong, Michael Mittmann et al. · Nature Biotechnology · 1997 · 978 citations

, , +14

COMPARISON OF PRIMARY HUMAN HEPATOCYTES AND HEPATOMA CELL LINE HEPG2 WITH REGARD TO THEIR BIOTRANSFORMATION PROPERTIES

Stefan Wilkening, Frank Stahl, Augustinus Bader · Drug Metabolism and Disposition · 2003 · 771 citations

, , +17

Hepatocyte function and extracellular matrix geometry: long‐term culture in a sandwich configuration

James Dunn, Martin L. Yarmush, H.G. Koebe et al. · The FASEB Journal · 1989 · 737 citations

, , +16