Science · 1995 · 521 citations · 45 references
Life SciencesCell BiologyMolecular BiologyDna RepairMolecular OncologyRadiobiologyCellular Radiation ResponseDna DamageDna Damage SignalingDna Double-strand Break RepairDna Strand BreaksDouble-strand Break RepairDna Damage Repair PathwaysDna Damage Response SignalingDna Repair MechanismsDna Strand Break RepairDna-pk SignalingDna-pkcsRepair Of Ionizing Radiation-induced Breaks
The radiosensitive rodent mutant cell line xrs-5 is defective in DNA double-strand break repair and lacks the Ku component of the DNA-activated protein kinase, DNA-PK. Here radiosensitive human cell lines were analyzed for DNA-PK activity and for the presence of related proteins. The radiosensitive human malignant glioma M059J cell line was found to be defective in DNA double-strand break repair, but fails to express the p350 subunit of DNA-PK. These results suggest that DNA-PK kinase activity is involved in DNA double-strand break repair.
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RAG-1-deficient mice have no mature B and T lymphocytes
Peter Mombaerts, John Iacomini, Randall S. Johnson et al. · Cell · 1992 · 2.9K citations
Life Sciences, Genetics, Immunology +13
Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination
Guillermo E. Taccioli, Tanya Gottlieb, T Blunt et al. · Science · 1994 · 636 citations