Concepedia

Dna-pkcs

DNA-PKcs is a serine/threonine protein kinase that belongs to the phosphatidylinositol 3-kinase-related kinase family and functions as the catalytic subunit of the DNA-dependent protein kinase complex, essential for the non-homologous end joining pathway of DNA double-strand break repair.

637

Publications

49.6K

Citations

3.2K

Authors

849

Institutions

Publications per year

2017–2026

114

Variants

Dna-dependent Protein Kinase Catalytic SubunitPrkdc

Parents

Publications

637

ATM Phosphorylates Histone H2AX in Response to DNA Double-strand Breaks

Sandeep Burma, Benjamin P. Chen, Michael Murphy et al. · Journal of Biological Chemistry · 2001 · 1.9K citations · Full text

, , +17

The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen

Tanya Gottlieb, Stephen P. Jackson · Cell · 1993 · 1.2K citations

, , +14

Substrate Specificities and Identification of Putative Substrates of ATM Kinase Family Members

Seong‐Tae Kim, Dae‐Sik Lim, Christine E. Canman et al. · Journal of Biological Chemistry · 1999 · 814 citations · Full text

, , +15

DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

Katharine O. Hartley, David A. Gell, Graeme C.M. Smith et al. · Cell · 1995 · 741 citations · Full text

, , +12

Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells

Andrew J. Pierce, Peng Hu, Mingguang Han et al. · Genes & Development · 2001 · 524 citations · Full text

, , +17

1–5 of 637

Authors

3.2K

  1. SP
    Susan P. Lees‐Miller

    University of Calgary, Canada

    37 publications · 4.9K citations

    30

    h-index

  2. DJ
    David J. Chen

    The University of Texas Southwestern Medical Center, United States

    34 publications · 6.6K citations

    29

    h-index

  3. KM
    Katheryn Meek

    Michigan State University, United States

    24 publications · 2.2K citations

    22

    h-index

  4. BP
    Benjamin P.C. Chen

    The University of Texas Southwestern Medical Center, United States

    24 publications · 2.5K citations

    21

    h-index

  5. PZ
    Ping‐Kun Zhou

    Beijing Radiation Center, China

    23 publications · 986 citations

    18

    h-index

1–5 of 3.2K

Institutions

849

  1. The University of Texas Southwestern Medical Center

    Dallas, United States

    36 h-index

    224 publications

    19.6K citations

  2. University of Calgary

    Calgary, Canada

    30 h-index

    119 publications

    15.9K citations

  3. Michigan State University

    East Lansing, United States

    21 h-index

    77 publications

    7.5K citations

  4. University of Cambridge

    Cambridge, United Kingdom

    18 h-index

    72 publications

    10.8K citations

  5. Beijing Radiation Center

    Beijing, China

    18 h-index

    161 publications

    7.5K citations

  6. Harvard University

    Cambridge, United States

    18 h-index

    66 publications

    8K citations

  7. Memorial Sloan Kettering Cancer Center

    New York, United States

    15 h-index

    55 publications

    8K citations

  8. Howard Hughes Medical Institute

    Chevy Chase, United States

    15 h-index

    59 publications

    9.1K citations

1–8 of 849

Venues

  1. Journal of Biological Chemistry

    JBC · 43 publications · 7.2K citations

    38

    h-index

  2. Nucleic Acids Research

    55 publications · 3.8K citations

    34

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 26 publications · 3.3K citations

    25

    h-index

  4. Molecular and Cellular Biology

    MCB · 24 publications · 2.7K citations

    22

    h-index

  5. PubMed

    Repository · 24 publications · 1.7K citations

    19

    h-index

1–5