FEBS Letters · 1990 · 42 citations · 14 references
Life SciencesBiochemistryImmunologyClinical BiochemistryInflammationMonoclonal AntibodiesComplement SystemProtein DegradationCollagen DegradationCollagen Degradation InhibitionComplement ComponentsMonoclonal Antibody RecognitionProteolytic ActivityProteolytic Enzyme ActivityProteolytic PathwaysType Ii Collagen Degradation
The activated first component of human complement, C1-s, was shown to cleave type I and II collagen and gelatin. The proteolytic activity was heat labile and was inhibited by a monoclonal antibody (M241) which recognized light chain of active human C1-s or by a serine protease inhibitor, DFP, but not by a chelating agent.
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