Concepedia

1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine (VNP40101M): I. Direct inhibition of O 6 -alkylguanine-DNA alkyltransferase (AGT) by electrophilic species generated by decomposition

Philip G. Penketh, K. Shyam, Raymond P. Baumann, Joanna S. Remack, Thomas P. Brent, Alan C. Sartorelli

Cancer Chemotherapy and Pharmacology · 2004 · 37 citations · 28 references

DOI

Concepts

References

28

Transfection and expression of human <i>O</i><sup>6</sup>-methylguanine-DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: the role of MGMT in protection against the genotoxic effects of alkylating agents

Kaina Bernd, Gerhard Fritz, Sankar Mitra et al. · Carcinogenesis · 1991 · 220 citations

, , +16

Inactivation of glutathione reductase by 2-chloroethyl nitrosourea-derived isocyanates

John R. Babson, Donald J. Reed · Biochemical and Biophysical Research Communications · 1978 · 186 citations

, , +5

Severe generalized glutathione reductase deficiency after antitumor chemotherapy with BCNU" [1,3-bis(chloroethyl)-1-nitrosourea].

Henri Frischer, Tanveer Ahmad · PubMed · 1977 · 173 citations

, , +10

DNA repair methyltransferase (Mgmt) knockout mice are sensitive to the lethal effects of chemotherapeutic alkylating agents

Brian Glassner · Mutagenesis · 1999 · 149 citations · Full text

, , +14

The mechanism of action of the nitrosourea anti-tumor drugs on thioredoxin reductase, glutathione reductase and ribonucleotide reductase

Karin U. Schallreuter, Florence K. Gleason, John M. Wood · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · 1990 · 121 citations

, , +12