Organic Letters · 2001 · 50 citations · 17 references
PharmacyChemistryMedicinal ChemistryDrug DiscoveryMolecular VirologySynthetic Medicinal ChemistryAntiretroviral TherapyAntiviral AgentsAntiviral PharmacologyAntiviral TherapyEnzyme InhibitionAntiviral Drug DesignAntiviral Structure-activity RelationshipsChiral Intermediate ProductionHiv Antiretroviral TherapyNon-nucleoside Reverse Transcriptase InhibitorsNucleoside Analogue AntiviralsNucleoside Reverse Transcriptase InhibitorsProtease Inhibitors
[reaction: see text] Chiral aziridine derivative 1 was prepared from D-tartaric acid. This compound could be utilized as a common intermediate for the synthesis of hydroxyethylamine class HIV protease inhibitors such as saquinavir, amprenavir, or nelfinavir.
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