Synthesis of a Chiral Aziridine Derivative as a Versatile Intermediate for HIV Protease Inhibitors

Abstract

[reaction: see text] Chiral aziridine derivative 1 was prepared from D-tartaric acid. This compound could be utilized as a common intermediate for the synthesis of hydroxyethylamine class HIV protease inhibitors such as saquinavir, amprenavir, or nelfinavir.