Spontaneous contractile activity of isolated ovarian human vein. A dual influence of prostacyclin (PGI2)

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

Salvador Moncada, Ryszard J. Gryglewski, S Bunting et al. · Nature · 1976 · 3.6K citations

Thrombopoiesis, Thrombosis, Biochemistry +12

Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides

Ryszard J. Gryglewski, Stuart Bunting, Salvador Moncada et al. · Prostaglandins · 1976 · 1K citations

Inflammation, Thrombosis, Thrombopoiesis +15

HUMAN ARTERIAL AND VENOUS TISSUES GENERATE PROSTACYCLIN (PROSTAGLANDIN X), A POTENT INHIBITOR OF PLATELET AGGREGATION

Salvador Moncada, E.A. Higgs, John R. Vane · The Lancet · 1977 · 886 citations

Thrombopoiesis, Thrombosis, Health Sciences +13

Prostacyclin (PGX) is the endogeneous metabolite responsible for relaxation of coronary arteries induced by arachidonic acid

Gregory J. Dusting, Salvador Moncada, John R. Vane · Prostaglandins · 1977 · 412 citations

Coronary Arteries, Biochemistry, Cardiovascular Disease +10

Some properties of the smooth muscle of rabbit portal vein

Mollie E. Holman, C. B. Kasby, M. B. Suthers et al. · The Journal of Physiology · 1968 · 132 citations · Full text

Muscle Function, Topographical Anatomy, Peripheral Nerve +22