Urocortin induces positive inotropic effect in rat heart

Eva Calderón-Sánchez, Carmen Delgado, Gema Ruiz‐Hurtado, Alejandro Domínguez‐Rodríguez, Victoria Cachofeiro, María Rodríguez-Moyano, Ana M. Gómez, Antonio Ordóñez, Tarik Smani

Cardiovascular Research · 2009 · 39 citations · 34 references

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Abstract

Our results show that Ucn evokes potent positive inotropic and lusitropic effects mediated, at least in part, by an increase in I(CaL) and [Ca(2+)](i) transient amplitude. These effects may involve the activation of Epac, PKC, and MAPK signalling pathways.

References

34