Modulation of Sodium Channel Inactivation Gating by a Novel Lactam: Implications for Seizure Suppression in Chronic Limbic Epilepsy

Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.

Bertil Hille · The Journal of General Physiology · 1977 · 1.8K citations · Full text

Local Pharmacology, Anesthetic Mechanism, Pharmacotherapy +19

EPILEPSY AND THE TEMPORAL LOBES

J. H. Margerison, J Corsellis · Brain · 1966 · 1.3K citations

Neuropsychology, Brain Function, Neurolinguistics +24

A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation.

James W. West, D E Patton, Todd Scheuer et al. · Proceedings of the National Academy of Sciences · 1992 · 833 citations

Protein Chemistry, Molecular Physiology, Signal Transduction +15

Lidocaine block of cardiac sodium channels.

Bruce P. Bean, Charles J. Cohen, Richard W. Tsien · The Journal of General Physiology · 1983 · 657 citations · Full text

Cardiac Muscle, Channelopathies, Mum Lidocaine +15

The Investigational Anticonvulsant Lacosamide Selectively Enhances Slow Inactivation of Voltage-Gated Sodium Channels

Adam C. Errington, Thomas Stöhr, Cara Heers et al. · Molecular Pharmacology · 2007 · 431 citations