Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation

Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function

Garrett M. Morris, David S. Goodsell, Robert S. Halliday et al. · Journal of Computational Chemistry · 1998 · 10.7K citations

Engineering, Molecular Biology, Computational Chemistry +22

Development and validation of a genetic algorithm for flexible docking 1 1Edited by F. E. Cohen

Gareth Jones, Peter Willett, Robert C. Glen et al. · Journal of Molecular Biology · 1997 · 6.6K citations

Medicine, Genetics, Computational Biology +4

Multiple sequence alignment with the Clustal series of programs

Nucleic Acids Research · 2003 · 4.9K citations · Full text

Engineering, Molecular Biology, Genomics +21

Human DNA methylomes at base resolution show widespread epigenomic differences

Ryan Lister, Mattia Pelizzola, Robert H. Dowen et al. · Nature · 2009 · 4.7K citations · Full text

Chromatin, Human Dna Methylomes, Chromatin Remodeling +10

Evaluation and Reparametrization of the OPLS-AA Force Field for Proteins via Comparison with Accurate Quantum Chemical Calculations on Peptides

George A. Kaminski, Richard A. Friesner, Julian Tirado‐Rives et al. · The Journal of Physical Chemistry B · 2001 · 4K citations

Engineering, Biochemistry, Protein Folding +15