Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

Ben Langmead, Cole Trapnell, Mihai Pop, +1

Genome biology

Embryonic Stem Cell Lines Derived from Human Blastocysts

James A. Thomson, Joseph Itskovitz‐Eldor, Sander S. Shapiro, +4

Science

Telomerase ActivityAdult Stem CellBiomedical EngineeringEmbryologyRegenerative Medicine +14

Bioconductor: open software development for computational biology and bioinformatics

Robert Gentleman, Vincent J. Carey, Douglas M. Bates, +22

Genome biology

DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development

Masaki Okano, Daphne W. Bell, Daniel A. Haber, +1

Cell

Histone ModificationsChromatinDna Methyltransferases Dnmt3aDevelopmental BiologyEpigenetic Change +11

A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells

B Bernstein, Tarjei S. Mikkelsen, Xiaohui Xie, +12

Cell

ChromatinDevelopmental BiologyChromatin StructureChromatin RemodelingMedicine +11

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

En Li, Timothy H. Bestor, Rudolf Jaenisch

Cell

Developmental BiologyEmbryonic LethalityEpigenetic ChangeGeneticsDna Methylation +6

Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome

Nathaniel D. Heintzman, Rhona Stuart, Gary C. Hon, +12

Nature Genetics

Histone ModificationsChromatinTranscriptional RegulationTranscriptional PromotersChromatin Structure +12

Genome-Wide Mapping of in Vivo Protein-DNA Interactions

David S. Johnson, A Mortazavi, R Myers, +1

Science

Histone modifications at human enhancers reflect global cell-type-specific gene expression

Nathaniel D. Heintzman, Gary C. Hon, R. David Hawkins, +18

Nature

Histone ModificationsChromatinChromatin StructureChromatin RemodelingNatural Sciences +9

Genome-scale DNA methylation maps of pluripotent and differentiated cells

Alexander Meissner, Tarjei S. Mikkelsen, Hongcang Gu, +10

Nature

ChromatinEpigenetic ChangeGeneticsDna MethylationEpigenomics +3