Collisions between Replication and Transcription Complexes Cause Common Fragile Site Instability at the Longest Human Genes

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

Vassilis G. Gorgoulis, Leandros-Vassilios Vassiliou, Panagiotis Karakaidos et al. · Nature · 2005 · 2K citations

Medicine, Molecular Biology, Oncology +16

Human Senataxin Resolves RNA/DNA Hybrids Formed at Transcriptional Pause Sites to Promote Xrn2-Dependent Termination

Konstantina Skourti-Stathaki, Nicholas Proudfoot, Natalia Gromak · Molecular Cell · 2011 · 811 citations · Full text

Life Sciences, Genetics, Molecular Biology +13

Inactivation of the SR Protein Splicing Factor ASF/SF2 Results in Genomic Instability

Xialu Li, James L. Manley · Cell · 2005 · 784 citations · Full text

Life Sciences, Genetics, Molecular Biology +10

Cotranscriptionally Formed DNA:RNA Hybrids Mediate Transcription Elongation Impairment and Transcription-Associated Recombination

Pablo Huertas, Andrés Aguilera · Molecular Cell · 2003 · 758 citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +10

R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells

Kefei Yu, Frédéric Chédin, Chih-Lin Hsieh et al. · Nature Immunology · 2003 · 746 citations

Life Sciences, Immunology, Molecular Biology +13