Concepedia

Synthesis and structure–activity relationships of 2-substituted-8-hydroxyadenine derivatives as orally available interferon inducers without emetic side effects

Yoshiaki Isobe, Masanori Tobe, Haruhisa Ogita, Ayumu Kurimoto, Tetsuhiro Ogino, Hajime Kawakami, Haruo Takaku, Hironao Sajiki, Kosaku Hirota, Hideya Hayashi

Bioorganic & Medicinal Chemistry · 2003 · 29 citations · 13 references

DOI

Concepts

References

13

Hepatitis C virus infection is associated with the development of hepatocellular carcinoma.

Izumu Saito, Tatsuo Miyamura, Akira Ohbayashi et al. · Proceedings of the National Academy of Sciences · 1990 · 1.1K citations · Full text

, , +16

To C or not to C: these are the questions

HJ Alter · Blood · 1995 · 284 citations · Full text

Tilorone Hydrochloride: Mode of Action

Gerald D. Mayer, Russell F. Krueger · Science · 1970 · 138 citations

, , +15

Induction of Interferon and Other Cytokines by Imiquimod and Its Hydroxylated Metabolite R-842 in Human Blood Cells <i>In Vitro</i>

Charles E. Weeks, Sheila J. Gibson · Journal of Interferon Research · 1994 · 109 citations

A phase I clinical trial of imiquimod, an oral interferon inducer, administered daily

Philip Savage, Vicki L. Horton, J. Moore et al. · British Journal of Cancer · 1996 · 107 citations · Full text

, , +2