Mutation and Cancer: Statistical Study of Retinoblastoma

Alfred G. Knudson

Proceedings of the National Academy of Sciences

Tumor BiologySomatic VariantTumor HeterogeneityPoisson StatisticsGenetics +11

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

Lawrence A. Donehower, Michele Harvey, Betty L. Slagle, +4

Nature

Knockout MouseSpontaneous TumoursMedicinePathologyCell Death +7

Tumor spectrum analysis in p53-mutant mice

Tyler Jacks, Lee Ann Remington, Bart O. Williams, +4

Current Biology

Tumor BiologyTumor HeterogeneityTumor Spectrum AnalysisMedicineCell Biology +1

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

Laura R. Livingstone, Alicia White, Jason Sprouse, +3

Cell

Wild-type P53Genome InstabilityCell RegulationCell DivisionGenetics +8

Mutator phenotype may be required for multistage carcinogenesis.

L A Loeb

PubMed

MedicineMutator PhenotypeCancer GeneticsCancer BiologyRadiation Oncology +1

Mutation and Cancer: A Model for Human Carcinogenesis2

Suresh H. Moolgavkar, Alfred G. Knudson

JNCI Journal of the National Cancer Institute

PathologyCell ProliferationTarget Stem CellsTumor BiologyCancer Research +14

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

Yuxin Yin, Michael A. Tainsky, Farideh Z. Bischoff, +2

Cell

Cell RegulationCell ControlMedicineGeneticsMutant P53 Alleles +5

Spontaneous and carcinogen–induced tumorigenesis in p53–deficient mice

Michele Harvey, Mark J. McArthur, Charles A. Montgomery, +3

Nature Genetics

Tumor BiologyMedicineCancer Cell BiologyTumor SuppressorCancer Biology +3

In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice.

Michele Harvey, Arthur Sands, Robert S. Weiss, +7

PubMed

How many mutations are required for tumorigenesis? implications from human cancer data

Allan Balmain, J. Carl Barrett, Harold L. Moses, +1

Molecular Carcinogenesis

Tumor BiologyRadiation OncologyGenome InstabilityEngineeringSomatic Variant +11