Allelic losses on chromosome arm 10q and mutation of the PTEN ( MMAC1 ) tumour suppressor gene in primary and metastatic malignant melanomas

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

Peter A. Steck, Mark A. Pershouse, Samar A. Jasser et al. · Nature Genetics · 1997 · 2.8K citations

Life Sciences, Genetics, Molecular Genetics +11

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

Danny Liaw, Jing Li, Patricia L. M. Dahia et al. · Nature Genetics · 1997 · 2.1K citations

Life Sciences, Genetics, Molecular Genetics +16

Pten is essential for embryonic development and tumour suppression

Antonio Di Cristofano, Bárbara Pesce, Carlos Cordon‐Cardo et al. · Nature Genetics · 1998 · 1.5K citations

Life Sciences, Developmental Biology, Molecular Genetics +14

Crystal Structure of the PTEN Tumor Suppressor

Jie‐Oh Lee, Haijuan Yang, Maria-Magdalena Georgescu et al. · Cell · 1999 · 1K citations · Full text

Life Sciences, Molecular Biology, Oncology +14

TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta.

Dongmei Li, Hong Sun · PubMed · 1997 · 875 citations

Life Sciences, Cell Biology, Molecular Biology +13