Photochemical substitution of olefins and aromatic compounds with difluoromethyl radicals bearing ester and phosphonate groups

Some influences of fluorine in bioorganic chemistry

David O’Hagan, Henry S. Rzepa · Chemical Communications · 1997 · 472 citations

Natural Sciences, Biochemistry, Chemistry +6

The synthesis and metal binding characteristics of novel, isopolar phosphonate analogues of nucleotides

G. Michael Blackburn, David E. Kent, Friedrich Kolkmann · Journal of the Chemical Society Perkin Transactions 1 · 1984 · 228 citations

Life Sciences, Biochemistry, Chemistry +11

Design, Synthesis, and Biological Activity of a Difluoro-Substituted, Conformationally Rigid Vigabatrin Analogue as a Potent γ-Aminobutyric Acid Aminotransferase Inhibitor

Yue Pan, Jian Qiu, Richard B. Silverman · Journal of Medicinal Chemistry · 2003 · 224 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Phosphonates as mimics of phosphate biomolecules: ab initio calculations on tetrahedral ground states and pentacoordinate intermediates for phosphoryl transfer

Gregory R. J. Thatcher, A. Stewart Campbell · The Journal of Organic Chemistry · 1993 · 142 citations

Natural Sciences, Biochemistry, Chemistry +11

Why Is Phosphonodifluoromethyl Phenylalanine a More Potent Inhibitory Moiety Than Phosphonomethyl Phenylalanine Toward Protein-Tyrosine Phosphatases

L. Chen, Li Wu, Akihisa Otaka et al. · Biochemical and Biophysical Research Communications · 1995 · 111 citations

Life Sciences, Medicinal Chemistry, Pharmacology +11