Concepedia

Peptide-Cleaving Catalyst Selective for Peptide Deformylase

Pil Seok Chae, Myoung-Soon Kim, Chul-Seung Jeung, Seong Du Lee, Hwangseo Park, Sangyoub Lee, Junghun Suh

Journal of the American Chemical Society · 2005 · 63 citations · 5 references

DOI

Concepts

Abstract

A peptide-cleaving catalyst selective for peptide deformylase (PDF) was obtained from a library containing about 15 000 catalyst candidates. The catalyst cleaved the polypeptide backbone of PDF at Gln(152)-Arg(153). Docking simulations suggested multiple modes of interactions in the complex formed between the catalyst and PDF.

References

5

Multicomponent Reactions with Isocyanides

Alexander Dömlingꝉ, Ivar Ugi · Angewandte Chemie International Edition · 2000 · 4K citations

, , +14

MutY catalytic core, mutant and bound adenine structures define specificity for DNA repair enzyme superfamily

Yue Guan, Raymond C. Manuel, A.S. Arvai et al. · Nature Structural Biology · 1998 · 325 citations

, , +17

New strategy for selective protein cleavage

Ho Cho, Peter G. Schultz · Journal of the American Chemical Society · 1990 · 135 citations

, , +5

Unusual reactivity of prostacyclin: rational drug design through physical organic chemistry

A. J. Kresge · Accounts of Chemical Research · 1987 · 43 citations

, , +8

Identification and Quantification of Feathers, Down, and Hair of Avian and Mammalian Origin Using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry

Klaus Hollemeyer, Wolfgang Altmeyer, Elmar Heinzle · Analytical Chemistry · 2002 · 42 citations

, , +17