Vinblastine Sulfate in Hodgkin's Disease in Pregnancy

Abstract

Case Studies1 July 1964Vinblastine Sulfate in Hodgkin's Disease in PregnancyARNOLD I. ROSENZWEIG, QUINTOUS E. CREWS JR., HERBERT G. HOPWOODARNOLD I. ROSENZWEIGSearch for more papers by this author, QUINTOUS E. CREWS JR.Search for more papers by this author, HERBERT G. HOPWOODSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-108 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHodgkin's disease is a malignancy commonly found in women of child-bearing age. In one study of Hodgkin's disease in women 15 to 50 years old, the incidence of pregnancy was as high as 33 per cent (1). In a second group, no difference was found in the frequency of pregnancy in Hodgkin's disease patients when compared with age-corrected normal controls (2). In the treatment of a young woman with active Hodgkin's disease, one may be faced with the problem of how to destroy the proliferating malignancy while doing no harm to the rapidly mitotic fetus. Irradiation is most helpful when...References1. SMITHSHEEHYROTHBERG RBTWH: Hodgkin's disease and pregnancy. Arch. Int. Med. (Chicago) 102: 777, 1958. CrossrefGoogle Scholar2. BARRYDIAMONDCRAVER RMHDLF: Influence of pregnancy on the course of Hodgkin's disease. Amer. J. Obstet. Gynec. 84: 445, 1962. CrossrefMedlineGoogle Scholar3. MYLES TJ: Hodgkin's disease and pregnancy. J. Obstet. Gynaec. Brit. Comm. 62: 884, 1955. CrossrefGoogle Scholar4. MURPHYDAGGKARNOFSKY MLCPDA: Comparison of teratogenic chemicals in the rat and chick embryos, Pediatrics 19: 701, 1957. MedlineGoogle Scholar5. HASKTN D: The effects of nitrogen mustard on the development of external body form in the fetal rat. Anat. Rec. 102: 493, 1948. CrossrefMedlineGoogle Scholar6. THIERSCHPHILLIPS JBFS: Effect of 4-amino-pteroylglutamic acid (Aminopterin) on early pregnancy. Proc. Soc. Exp. Biol. Med. 74: 204, 1950. CrossrefMedlineGoogle Scholar7. FRASERWALKERTRASLER FCBEDG: Experimental production of congenital cleft palate: Genetic and environmental factors. Pediatrics 19: 782, 1957. MedlineGoogle Scholar8. ZOET AG: Pregnancy complicating Hodgkin's disease. Northwest Med. 49: 373, 1950. MedlineGoogle Scholar9. FRENKELMEYERS EPMC: Acute leukemia and pregnancy. Ann. Intern. Med. 53: 656, 1960. LinkGoogle Scholar10. CUTTIS HJ: The effects of vincaleukoblastine on dividing cells in vivo. Cancer Res. 21: 168, 1960. Google Scholar11. JOHNSONWRIGHTSVOBODAVLONTIS ISHFGHJ Antitumor principles derived from vinca rosea linea: vincaleukoblastine and leurosine. Cancer Res. 20: 1016, 1960. MedlineGoogle Scholar12. FROSTGOLDWEINBRYAN JWMIJA: Clinical experience with vincaleukoblastine in far advanced Hodgkin's disease and various malignant states. Ann. Intern. Med. 56: 854, 1962. LinkGoogle Scholar13. FIRM VH: Congenital malformations in hamster embryos after treatment with vinblastine and vincristine. Science 141: 426, 1963. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ARNOLD I. ROSENZWEIG; QUINTOUS E. CREWSJR.; HERBERT G. HOPWOODFrom the Department of Obstetrics and Gynecology, U. S. Naval Hospital, Great Lakes, Ill.The opinions expressed in this paper are not necessarily those of the Navy Department.Requests for reprints should be addressed to Quintous E. Crews, Lt. Cmdr., MC, USN, U. S. Naval Hospital, Navy #926, c/o F.R.O., San Francisco, California 96635. 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DONALDSON, M.D., SAUL A. ROSENBERG, M.D., HENRY S. KAPLAN, M.D.Pregnancy outcome of patients treated for Hodgkin's disease.A controlled studyGenetic and related effects of Vinca rosea alkaloidsMultiple agent chemotherapy including bleomycin of non-hodgkin's lymphoma during pregnancyToxicity of Antineoplastic Agents in Man: Chromosomal Aberrations, Antifertility Effects, Congenital Malformations, and Carcinogenic PotentialImmunosuppressive and Cytotoxic Chemotherapy: Long-Term ComplicationsPHILIP S. SCHEIN, M.D., F.A.C.P., M.R.C.P., STANLEY H. WINOKUR, M.D.Effects of vinblastine and podophyllin on DBA mouse fetusesHuman Experiences Related to Adverse Drug Reactions to the Fetus or Neonate from Some Maternally Administered DrugsCombination chemotherapy in malignant diseaseBiological Activity of the Terpenoids and Their Derivatives — Recent AdvancesDiagnosis and Therapy of Malignant Lymphoma during PregnancyHODGKIN'S DISEASE AND PREGNANCYCYTOTOXIC DRUGS IN PREGNANCY. Review of Reported CasesSPECIAL PROBLEMS IN TOXICITY 1 July 1964Volume 61, Issue 1Page: 108-112KeywordsFetusesHodgkin lymphomaObstetrics and gynecologyPregnancySulfates ePublished: 1 December 2008 Issue Published: 1 July 1964 PDF downloadLoading ...