Mechanotransduction in bone tissue: The A214V and G171V mutations in Lrp5 enhance load-induced osteogenesis in a surface-selective manner

LDL Receptor-Related Protein 5 (LRP5) Affects Bone Accrual and Eye Development

Yaoqin Gong, Roger B. Slee, Georges Rawadi et al. · Cell · 2001 · 2.2K citations · Full text

Medicine, Developmental Biology, Endocrinology +10

High Bone Density Due to a Mutation in LDL-Receptor–Related Protein 5

Lynn M. Boyden, Junhao Mao, Joseph L. Belsky et al. · New England Journal of Medicine · 2002 · 1.6K citations · Full text

Medicine, Molecular Genetics, Oncology +17

Sclerostin Binds to LRP5/6 and Antagonizes Canonical Wnt Signaling

Xiaofeng Li, Heeseog Kang, Wenzhong Liu et al. · Journal of Biological Chemistry · 2005 · 1.4K citations · Full text

Medicine, Developmental Biology, Molecular Biology +17

Mechanical Stimulation of Bone in Vivo Reduces Osteocyte Expression of Sost/Sclerostin

Alexander G. Robling, Paul Niziolek, Lee Ann Baldridge et al. · Journal of Biological Chemistry · 2007 · 1.3K citations · Full text

Natural Sciences, Biochemistry, Molecular Biology +17

A Mutation in the LDL Receptor–Related Protein 5 Gene Results in the Autosomal Dominant High–Bone-Mass Trait

Randall D. Little, Colleen Folz, Susan P. Manning et al. · The American Journal of Human Genetics · 2002 · 1.3K citations · Full text

Medicine, Genetics, Molecular Genetics +12