Asymmetric Synthesis of Substituted Prolines from δ-Amino β-Ketoesters. Methyl (2<i>S</i>,5<i>R</i>)-(+)-5-Phenylpyrrolidine-2-carboxylate

Abstract

[reaction: see text]. Metal carbenoid chemistry is used to convert delta-amino beta-ketoesters into 5-substituted 3-oxo prolines, which expands the utility of this class of polyfunctionalized chiral building blocks.