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Small-Molecule Ligands of GD2 Ganglioside, Designed from NMR Studies, Exhibit Induced-Fit Binding and Bioactivity

BiochemistryG Protein-coupled ReceptorMedicineGd2 GangliosideNatural SciencesGlycobiologySmall-molecule LigandsNmr StudiesNon-peptide LigandMolecular RecognitionPharmacologyCarbohydrate-protein InteractionSmall MoleculesDrug DiscoveryBio-orthogonal Chemistry