Concepedia

Induced Fit Binding

Induced Fit Binding is a biochemical mechanism of drug-receptor interaction in which the initial binding of a ligand to a target protein induces a conformational change in the protein’s structure, thereby enhancing the complementarity and affinity between the ligand and its binding site.

246

Publications

15.4K

Citations

1.2K

Authors

429

Institutions

Publications per year

2017–2026

45

Parents

Publications

246

Induced fit, conformational selection and independent dynamic segments: an extended view of binding events

Péter Csermely, Robin Palotai, Ruth Nussinov · Trends in Biochemical Sciences · 2010 · 820 citations · Full text

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Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners

Christopher J. Oldfield, Jingwei Meng, Jack Yang et al. · BMC Genomics · 2008 · 595 citations · Full text

, , +16

Structural Evidence for Induced Fit as a Mechanism for Antibody-Antigen Recognition

James M. Rini, Ursula Schulze‐Gahmen, Ian A. Wilson · Science · 1992 · 525 citations

, , +16

Structure of Factor-inhibiting Hypoxia-inducible Factor (HIF) Reveals Mechanism of Oxidative Modification of HIF-1α

Jonathan M. Elkins, Kirsty S. Hewitson, Christopher J. Schofield · Journal of Biological Chemistry · 2003 · 390 citations · Full text

, , +16

Anchor residues in protein–protein interactions

Deepa Rajamani, Spencer Thiel, Sándor Vajda et al. · Proceedings of the National Academy of Sciences · 2004 · 337 citations · Full text

, , +17

1–5 of 246

Authors

1.2K

  1. AV
    Angelo Vedani

    University of Basel, Switzerland

    6 publications · 178 citations

    6

    h-index

  2. MA
    Markus A. Lill

    Purdue University West Lafayette, United States

    5 publications · 138 citations

    5

    h-index

  3. HC
    Haifeng Chen

    Shanghai Jiao Tong University, China

    3 publications · 102 citations

    3

    h-index

  4. JZ
    Jian Zhang

    Shanghai Jiao Tong University, China

    3 publications · 88 citations

    3

    h-index

  5. MD
    Max Dobler

    ETH Zurich, Switzerland

    3 publications · 86 citations

    3

    h-index

1–5 of 1.2K

Institutions

429

  1. Centre National de la Recherche Scientifique

    Paris, France

    9 h-index

    37 publications

    1.7K citations

  2. Scripps Research Institute

    San Diego, United States

    7 h-index

    27 publications

    3.8K citations

  3. University of California, San Francisco

    San Francisco, United States

    5 h-index

    19 publications

    1.3K citations

  4. Howard Hughes Medical Institute

    Chevy Chase, United States

    5 h-index

    10 publications

    536 citations

  5. McGill University

    Montreal, Canada

    5 h-index

    19 publications

    632 citations

  6. University of California, Los Angeles

    Los Angeles, United States

    5 h-index

    12 publications

    861 citations

  7. University of California San Diego

    San Diego, United States

    4 h-index

    11 publications

    290 citations

  8. Kyoto University

    Kyoto, Japan

    4 h-index

    9 publications

    470 citations

1–8 of 429

Venues

  1. Biochemistry

    18 publications · 619 citations

    16

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 14 publications · 1.4K citations

    14

    h-index

  3. Journal of the American Chemical Society

    JACS · 13 publications · 1.5K citations

    13

    h-index

  4. Journal of Molecular Biology

    JMB · 12 publications · 855 citations

    12

    h-index

  5. Journal of Medicinal Chemistry

    12 publications · 498 citations

    12

    h-index

1–5