Concepedia

Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1

Jingbo Xiao, Zaohua Huang, Catherine Z. Chen, Irina U. Agoulnik, Noel Southall, Xin Hu, Raisa E. Jones, Marc Ferrer, Wei Zheng, Alexander I. Agoulnik,

Nature Communications · 2013 · 70 citations · 29 references

DOIFull text

Open access

Concepts

References

29

Heart Disease and Stroke Statistics—2011 Update

Véronique L. Roger, Alan S. Go, Donald M. Lloyd‐Jones et al. · Circulation · 2010 · 6.2K citations

, , +10

Aromatic substituent constants for structure-activity correlations

Corwin Hansch, Albert J. Leo, Stefan Unger et al. · Journal of Medicinal Chemistry · 1973 · 1.3K citations

, , +14

Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial

John R. Teerlink, Gad Cotter, Beth A. Davison et al. · The Lancet · 2012 · 908 citations

, , +11

Quantitative high-throughput screening: A titration-based approach that efficiently identifies biological activities in large chemical libraries

James Inglese, Douglas S. Auld, Ajit Jadhav et al. · Proceedings of the National Academy of Sciences · 2006 · 820 citations · Full text

, , +6

Activation of Orphan Receptors by the Hormone Relaxin

Sheau Yu Hsu, Koji Nakabayashi, Shinya Nishi et al. · Science · 2002 · 786 citations

, , +17