MEK inhibitor effective against proliferation in breast cancer cell

BRAF mutation predicts sensitivity to MEK inhibition

David B. Solit, Levi A. Garraway, Christine A. Pratilas et al. · Nature · 2005 · 1.3K citations · Full text

Life Sciences, Genetics, Molecular Biology +10

Selumetinib-Enhanced Radioiodine Uptake in Advanced Thyroid Cancer

Alan L. Ho, Ravinder K. Grewal, Rébecca Leboeuf et al. · New England Journal of Medicine · 2013 · 829 citations · Full text

Medicine, Endocrinology, Nuclear Medicine +16

Identification of miRNomes in Human Liver and Hepatocellular Carcinoma Reveals miR-199a/b-3p as Therapeutic Target for Hepatocellular Carcinoma

Jin Hou, Li Lin, Weiping Zhou et al. · Cancer Cell · 2011 · 692 citations · Full text

Medicine, Molecular Biology, Oncology +17

Genome and Transcriptome Sequencing in Prospective Metastatic Triple-Negative Breast Cancer Uncovers Therapeutic Vulnerabilities

David W. Craig, Joyce O’Shaughnessy, Jeffrey Kiefer et al. · Molecular Cancer Therapeutics · 2012 · 225 citations · Full text

Medicine, Genetics, Oncology +17

Inhibition of MEK and PI3K/mTOR Suppresses Tumor Growth but Does Not Cause Tumor Regression in Patient-Derived Xenografts of RAS-Mutant Colorectal Carcinomas

Giorgia Migliardi, Francesco Sassi, Davide Torti et al. · Clinical Cancer Research · 2012 · 194 citations · Full text

Medicine, Molecular Medicine, Pharmacology +17