An aluminum-based rat model for Alzheimer’s disease exhibits oxidative damage, inhibition of PP2A activity, hyperphosphorylated tau, and granulovacuolar degeneration

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

Inge Grundke‐Iqbal, Khurshid Iqbal, Y C Tung et al. · Proceedings of the National Academy of Sciences · 1986 · 3.6K citations · Full text

Life Sciences, Neurobiology, Neuroscience +15

Oxidative Damage Is the Earliest Event in Alzheimer Disease

Akihiko Nunomura, George Perry, Gjumrakch Aliev et al. · Journal of Neuropathology & Experimental Neurology · 2001 · 1.9K citations · Full text

Life Sciences, Neurology, Neuroscience +17

The Dialysis Encephalopathy Syndrome

Allen C. Alfrey, Gary R. LeGendre, William D. Kaehny · New England Journal of Medicine · 1976 · 1.6K citations

Medicine, Nephrology, Neurology +14

Production of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing

Mikio Shoji, Todd E. Golde, Jorge Ghiso et al. · Science · 1992 · 1.4K citations

Life Sciences, Biochemistry, Molecular Biology +14

A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau

Virginia M.‐Y. Lee, Brian J. Balin, László Ötvös et al. · Science · 1991 · 1.4K citations

Life Sciences, Biochemistry, Molecular Biology +17