Hypoxia stimulates proliferation of human hepatoma cells through the induction of hexokinase II expression

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

G L Wang, Bing‐Hua Jiang, E A Rue et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations

Life Sciences, Cell Biology, Molecular Biology +17

Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial

Josep M. Llovet, María Isabel Real, Xavier Montañá et al. · The Lancet · 2002 · 3.5K citations

Medicine, Oncology, Surgery +16

Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

Peter Carmeliet, Yuval Dor, Jean-Marc Herbert et al. · Nature · 1998 · 2.5K citations

Medicine, Cancer Biology, Cell Biology +16

Cellular and developmental control of O₂ homeostasis by hypoxia-inducible factor 1α

Narayan V. Iyer, Lori E. Kotch, Faton Agani et al. · Genes & Development · 1998 · 2.5K citations · Full text

Life Sciences, Developmental Biology, Molecular Biology +16

Hypoxia-inducible Factor 1α (HIF-1α) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System under Normoxic Conditions

Susana Alicia Salceda, J. Jaime · Journal of Biological Chemistry · 1997 · 1.7K citations · Full text

Life Sciences, Biochemistry, Cell Biology +15