Evaluation of functional and binding assays in cells expressing either recombinant or endogenous hERG channel

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

Ji-Hu Zhang, Thomas D.Y. Chung, Kevin R. Oldenburg · SLAS DISCOVERY · 1999 · 6.9K citations · Full text

A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel

Michael C. Sanguinetti, Changan Jiang, Mark Curran et al. · Cell · 1995 · 2.4K citations · Full text

Cardiac Muscle, Cardiomyopathy, Molecular Physiology +10

A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

Mark Curran, Igor Splawski, Katherine W. Timothy et al. · Cell · 1995 · 2.3K citations · Full text

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Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents.

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Cardiac Muscle, Electrophysiological Evaluation, Heart Failure +14

MiRP1 Forms IKr Potassium Channels with HERG and Is Associated with Cardiac Arrhythmia

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