Evidence of a Role for Osteoprotegerin in the Pathogenesis of Pulmonary Arterial Hypertension

Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density

W. Scott Simonet, Dave Lacey, Colin R. Dunstan et al. · Cell · 1997 · 5.1K citations · Full text

Medicine, Biochemistry, Molecular Biology +13

osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification

Nathan Bucay, Ildiko Sarosi, Colin R. Dunstan et al. · Genes & Development · 1998 · 2.5K citations · Full text

Medicine, Developmental Biology, Physiology +17

Heterozygous germline mutations in BMPR2, encoding a TGF-β receptor, cause familial primary pulmonary hypertension

Kirk B. Lane, Rajiv D. Machado, Michael W. Pauciulo et al. · Nature Genetics · 2000 · 1.5K citations

Life Sciences, Genetics, Molecular Genetics +12

Osteoprotegerin Is a Receptor for the Cytotoxic Ligand TRAIL

John G. Emery, Peter McDonnell, Michael Brigham Burke et al. · Journal of Biological Chemistry · 1998 · 1.2K citations · Full text

Life Sciences, Cell Biology, Pharmacology +17

Increased Interleukin-1 and Interleukin-6 Serum Concentrations in Severe Primary Pulmonary Hypertension

Marc Humbert, Gianpaola Monti, F Brénot et al. · American Journal of Respiratory and Critical Care Medicine · 1995 · 786 citations

Medicine, Immunology, Pathobiology +16