Helicobacter pylori CagA interacts with E-cadherin and deregulates the β-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells

E-cadherin germline mutations in familial gastric cancer

Parry Guilford, Justin Hopkins, James Harraway et al. · Nature · 1998 · 1.7K citations

Medicine, Pathology, Cancer Genetics +3

Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach.

Martin J. Blaser, Harry Kleanthous, Timothy L. Cover et al. · PubMed · 1995 · 1.6K citations

Epidemiology, Gastrointestinal Oncology, Medicine +11

Translocation of <i>Helicobacter pylori</i> CagA into Gastric Epithelial Cells by Type IV Secretion

Stefan Odenbreit, Jürgen Püls, Bettina Sedlmaier et al. · Science · 2000 · 1.3K citations

Peptic Ulcer Disease, Protein Secretion, Virulence Factor +15

SHP-2 Tyrosine Phosphatase as an Intracellular Target of <i>Helicobacter pylori</i> CagA Protein

Hideaki Higashi, Ryouhei Tsutsumi, Syuichi Muto et al. · Science · 2002 · 1K citations

Severe Gastritis, Protein Function, Signal Transduction +15

Canonical Wnt signals are essential for homeostasis of the intestinal epithelium

Daniel Pinto, Alex Gregorieff, Harry Begthel et al. · Genes & Development · 2003 · 1K citations · Full text