Development of a High-Throughput Screening Paradigm for the Discovery of Small-Molecule Modulators of Adenylyl Cyclase: Identification of an Adenylyl Cyclase 2 Inhibitor

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

Ji-Hu Zhang, Thomas D.Y. Chung, Kevin R. Oldenburg · SLAS DISCOVERY · 1999 · 7K citations · Full text

Pharmacy, Medicinal Chemistry, Drug Design +16

Ras-dependent Mitogen-activated Protein Kinase Activation by G Protein-coupled Receptors

Gregory J. Della Rocca, Tim van Biesen, Yehia Daaka et al. · Journal of Biological Chemistry · 1997 · 454 citations · Full text

Life Sciences, Cell Biology, Pharmacology +16

Type 5 Adenylyl Cyclase Disruption Increases Longevity and Protects Against Stress

Lin Yan, Dorothy E. Vatner, J. Patrick O’Connor et al. · Cell · 2007 · 351 citations · Full text

Education, Cell Biology, Molecular Biology +14

Genetic Elimination of Behavioral Sensitization in Mice Lacking Calmodulin-Stimulated Adenylyl Cyclases

Wei Feng, Chang-Shen Qiu, Susan J. Kim et al. · Neuron · 2002 · 263 citations · Full text

Life Sciences, Neurobiology, Neuroscience +12

Elevation of IL-6 in the allergic asthmatic airway is independent of inflammation but associates with loss of central airway function

Wendy Neveu, Jenna L. Allard, Danielle M. Raymond et al. · Respiratory Research · 2010 · 206 citations · Full text

Life Sciences, Immunology, Allergy +16