Familial Multifocal Fibrosclerosis

Abstract

Article1 May 1967Familial Multifocal FibrosclerosisFindings Suggesting that Retroperitoneal Fibrosis, Mediastinal Fibrosis, Sclerosing Cholangitis, Riedel's Thyroiditis, and Pseudotumor of the Orbit May Be Different Manifestations of a Single DiseaseDAVID E. COMINGS, M.D., K. B. SKUBI, M.D., F.A.C.P., J. VAN EYES, PH.D., M.D., ARNO G. MOTULSKY, M.D., F.A.C.P.DAVID E. COMINGS, M.D.Search for more papers by this author, K. B. SKUBI, M.D., F.A.C.P.Search for more papers by this author, J. VAN EYES, PH.D., M.D.Search for more papers by this author, ARNO G. MOTULSKY, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-5-884 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSclerosing Overgrowths of fibrous tissue have long been known to affect a number of widely separate organ systems. The terms retroperitoneal fibrosis, mediastinal fibrosis, sclerosing cholangitis, Riedel's sclerosing thyroiditis, and pseudotumor of the orbit reflect the multiple areas involved. Despite the tendency to treat these entities as independent diseases, an increasing number of patients has been reported with fibrotic involvement of more than one of the above areas. With the exception of the recent evidence that methysergide (Sansert®) may produce retroperitoneal fibrosis, the cause of these diverse disorders has remained unknown. The present report concerns two brothers, offspring of a...References1. ORMOND JK: Bilateral ureteral obstruction due to envelopment and compression by an inflammatory retroperitoneal process. J. Urol. 59: 1072, 1948. CrossrefMedlineGoogle Scholar2. HUTCHATKINSONLOQUVAM JARCGS: Perirenal (Gerota's) fascitis. J. Urol. 81: 76, 1959. CrossrefMedlineGoogle Scholar3. 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An anatomic and radiologic review with a report of four new cases and an explanation of pathogenesis. Radiology 75: 380, 1960. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Seattle, WashingtonFrom the Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, Wash.This study was supported in part by grant H 3091, National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to David E. Comings, M.D., Department of Medical Genetics, City of Hope Medical Center, Duarte, Calif. 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