An oncolytic conditionally replicating adenovirus for hormone-dependent and hormone-independent prostate cancer

A simplified system for generating recombinant adenoviruses

Tong‐Chuan He, Shibin Zhou, Luís Teixeira da Costa et al. · Proceedings of the National Academy of Sciences · 1998 · 3.2K citations

Life Sciences, Biotechnology, Molecular Biology +15

An Adenovirus Mutant That Replicates Selectively in p53- Deficient Human Tumor Cells

James R. Bischoff, David H. Kirn, Angelica Williams et al. · Science · 1996 · 1.8K citations

Medicine, Cancer Biology, Oncology +14

A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer

Fadlo R. Khuri, John Nemunaitis, Ian Ganly et al. · Nature Medicine · 2000 · 1.1K citations

Medicine, Oncology, Chemotherapy +8

A mutant oncolytic adenovirus targeting the Rb pathway produces anti-glioma effect in vivo

Juàn Fueyo, Candelaria Gomez‐Manzano, Ramón Alemany et al. · Oncogene · 2000 · 772 citations

Medicine, Molecular Biology, Oncology +16

Prostate attenuated replication competent adenovirus (ARCA) CN706: a selective cytotoxic for prostate-specific antigen-positive prostate cancer cells.

Ronald Rodríguez, Eric R. Schuur, Ho Yeong Lim et al. · PubMed · 1997 · 590 citations

Medicine, Molecular Biology, Oncology +14