Quinazolines as potent and highly selective PDE5 inhibitors as potential therapeutics for male erectile dysfunction

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Medicine, Pharmacology, Pharmacotherapy +12

4-Benzylamino-1-chloro-6-substituted Phthalazines:  Synthesis and Inhibitory Activity toward Phosphodiesterase 5

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Pharmacy, Medicinal Chemistry, Pharmacology +10

The Discovery of Tadalafil:  A Novel and Highly Selective PDE5 Inhibitor. 1: 5,6,11,11a-Tetrahydro-1<i>H</i>-imidazo[1‘,5‘:1,6]pyrido[3,4-<i>b</i>]indole-1,3(2<i>H</i>)-dione Analogues

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Pharmacy, Medicinal Chemistry, Pharmacology +16

Inhibition of Cyclic GMP-Binding Cyclic GMP-Specific Phosphodiesterase (Type 5) by Sildenafil and Related Compounds

Illarion V. Turko, Stephen A. Ballard, Sharron H. Francis et al. · Molecular Pharmacology · 1999 · 191 citations

Medicine, Pharmacology, Pharmacotherapy +15

Cyclic GMP Phosphodiesterase Inhibitors. 2. Requirement of 6-Substitution of Quinazoline Derivatives for Potent and Selective Inhibitory Activity

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Medicine, Medicinal Chemistry, Pharmacology +9