Molecular Pharmacology · 1999 · 191 citations · 30 references
MedicinePharmacologyPharmacotherapyMolecular PharmacologyPharmacodynamicsSignal TransductionCyclic Nucleotide SignalingEnzyme InhibitionErectile DysfunctionLigand BindingAllosteric Enzyme SitesAllosteric SitesCyclic Nucleotide PhosphodiesterasesDirected MutagenesisPde5 InhibitorsPhosphodiesterase InhibitionPhosphodiesterase Type 5 InhibitorsSignal Transduction By Cyclic Nucleotides
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Hydrogen bonding and biological specificity analysed by protein engineering
Alan R. Fersht, Jianping Shi, J.W. Knill-Jones et al. · Nature · 1985 · 1.1K citations