International Journal of Molecular Sciences · 2013 · 62 citations · 66 references
Life SciencesMolecular BiologyNeuroscienceDna RepairMitochondrial BiologyNeurodegenerationMitochondrial DysfunctionMolecular Basis Of NeurodegenerationNeurodegenerative DiseasesNeurodegenerative DisordersParkinson DiseaseParkinsonian DisordersAge-related Neurodegenerative MechanismsDefective Dna Repair PathwaysDna Damage Repair PathwaysDna Repair PathwaysDopaminergic NeurodegenerationDopaminergic NeuronsMitochondrial Base Excision RepairMitochondrial Dna Oxidative Damage
Parkinson's disease (PD) is one of the most common age-related neurodegenerative diseases. This pathology causes a significant loss of dopaminergic neurons in the Substantia Nigra. Several reports have claimed a role of defective nuclear and mitochondrial DNA repair pathways in PD etiology, in particular, of the Base Excision Repair (BER) system. In addition, recent findings, related to PD progression, indicate that oxidative stress pathways involving c-Abl and GST could also be implicated in this pathology. This review focuses on recently described networks most likely involved in an integrated manner in the course of PD.
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