Microsomal Prostaglandin E ₂ Synthase-1 Modulates the Response to Vascular Injury

Abstract

Deletion of mPGES-1 in mice attenuates neointimal hyperplasia after vascular injury, in part by regulating tenascin-C expression. This raises for consideration the therapeutic potential of mPGES-1 inhibitors as adjuvant therapy for percutaneous coronary intervention.