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Structure-Activity Relationships Among a New Class of Antiviral Heterosubstituted 2',3'-Dideoxynucleoside Analogues
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1995
Year
ImmunologyAntiviral DrugAntiviral Heterosubstituted 2',3'-DideoxynucleosideMedicinal ChemistryOxathiolanes 10Antiviral Drug DevelopmentCompound 16BiochemistryStructure-activity RelationshipsVirologyCell LinesHivPharmacologyAntiviral CompoundNatural SciencesAntiviral ResponseAntiviral TherapyNew ClassMedicineViral ImmunityDrug Discovery
Abstract 3′-Oxa-4′-thiocytidine nucleoside analogues 14–17 were prepared from oxathiolanes 10 and 11, and evaluated for activity against HIV-1 and HBV in vitro. The nucleoside analogues were found to possess potent activities against HIV-1 in a panel of cell lines. Compound 16 is moderately active against HBV in 2.2.15 cells.