The cefT gene of Acremonium chrysogenum C10 encodes a putative multidrug efflux pump protein that significantly increases cephalosporin C production

DNA sequencing with chain-terminating inhibitors

Frederick Sanger, S. Nicklen, Alan Coulson · Proceedings of the National Academy of Sciences · 1977 · 69.3K citations · Full text

Life Sciences, Microbiology, Molecular Biology +10

Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing

Steven Henikoff · Gene · 1984 · 4.2K citations

Life Sciences, Genetics, Molecular Biology +5

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

Suzanne L. Mansour, Kirk R. Thomas, Mario R. Capecchi · Nature · 1988 · 1.7K citations

Medicine, Genetics, Molecular Genetics +15

Transformation of Aspergillus based on the hygromycin B resistance marker from Escherichia coli

Peter J. Punt, Richard P. Oliver, Maria A. Dingemanse et al. · Gene · 1987 · 954 citations

Life Sciences, Biotechnology, Microbiology +10

Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters

Dominique Sanglard, Karl Kuchler, Françoise Ischer et al. · Antimicrobial Agents and Chemotherapy · 1995 · 817 citations

Life Sciences, Microbiology, Pharmacology +17