Nicotinamide improves glucose metabolism and affects the hepatic NAD-sirtuin pathway in a rodent model of obesity and type 2 diabetes

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

Jun Yoshino, Kathryn F. Mills, Myeong Jin Yoon et al. · Cell Metabolism · 2011 · 1.3K citations · Full text

Life Sciences, Biochemistry, Pharmacology +15

The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

Carles Cantó, Riekelt H. Houtkooper, Eija Pirinen et al. · Cell Metabolism · 2012 · 1.2K citations · Full text

Life Sciences, Biochemistry, Nutritional Sciences +12

SIRT1 Functionally Interacts with the Metabolic Regulator and Transcriptional Coactivator PGC-1α

Shino Nemoto, Marı́a M. Fergusson, Toren Finkel · Journal of Biological Chemistry · 2005 · 1K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +11

Inhibition of Silencing and Accelerated Aging by Nicotinamide, a Putative Negative Regulator of Yeast Sir2 and Human SIRT1

Kevin J. Bitterman, Rozalyn M. Anderson, Haim Cohen et al. · Journal of Biological Chemistry · 2002 · 998 citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

Lei Zhong, Agustina D’Urso, Debra Toiber et al. · Cell · 2010 · 996 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +10