MedicineHematologyPharmacologyClinical BiochemistryHematology PhysiologyHemostasisAnticoagulant TherapyAnticoagulation TherapyCoagulation AbnormalitiesCoagulation PhysiologyThrombin GenerationThrombosis PreventionFactor ViiaFactor Viii ActivationFactor Viii PhysiologyProthrombin Complex Concentrate UseThrombin Inhibition
Factor VIII inhibitor levels were measured on 261 occasions in 76 hemophilia-A inhibitor patients before and after prothrombin complex concentrate infusion at 13 treatment centers. A rise in inhibitor level to at least twice the pretreatment value occurred in 35 treatment episodes (13.5%), in 27 patients (36%). In 16 patients (21%), such an anamnestic immune response occurred with the first treatment. Factors predisposing to anamnestic responses may include patient idiosyncrasy, low pretreatment inhibitor levels, and exposure to concentrate over several days.
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A More Uniform Measurement of Factor VIII Inhibitors
Carol K. Kasper, Louis M. Aledort, David L. Aronson et al. · Thrombosis and Haemostasis · 1975 · 587 citations
Antihemophilic factor inhibitors. Management with prothrombin complex concentrates