Hepatic ACAT2 Knock Down Increases ABCA1 and Modifies HDL Metabolism in Mice

Abstract

The use of ASO6 revealed a new pathway by which the liver may contribute to HDL metabolism in mice. ACAT2 seems to be a hepatic player affecting the cholesterol fluxes fated to VLDL or to HDL, the latter via up-regulation of ABCA1.